HISTOGENESIS OF CONNECTIVE TISSUE. -" - 



to confu-e the picture. This area is bordered on either side by 

 the dermal fin-ray, beneath which an efferent blood-vt 

 descends, and alongside of which the return or afferent \. 

 ascend-- the tin; it i- covered only by the pavement cell- <.)f the 

 dermal epithelium, who-e outline- are -harply detined, lyiii at 

 a more -uperticial focal plain- than the connecti\e ti ue. The 

 chromaiophore- are ea-ilv reco-ui/ed both by their color, black 

 to yellow, and by their peculiar branching form. -<> that e\ en 

 iho-e re|,iti\ ely or almost entirely de\oid of color can be ea-ilv 

 ilitfereniiated from ihe -mailer colorle connective ti--ue cell-. 

 Moivo\er, th,- chroma tophores are prone to lie in immediate 

 relation to the tin-ray- and to the blood-\ v el-. 



In com lu-ion I de-ire to einpha-i/e the opinion that in the 



-tlldv of hi-to-i-lie-i- of conilecti\e li lie \\ e Illll-t take into 



con-ideratioii the (..ndition- -urroimdiiiK the living cell- and 

 dra\\ i OIK In-ion- troin "ti\el" ti--ne only in the Irjit of our 

 knou 1. t the li\ i: 



I turni-li (oin In-' 'ill- li\iiu cell- mu.-t be ob-er\ed 



under noriii.il condition- and not merely under tho-e mo-t un- 

 u-iial. or e\en pathological, conditions \\hich -urroimd 'lie ob- 

 servation <-ither in the me-enterv -tudieil by 



Meinmiiu -mil other-, open l the ciitiii-in of the pi'e-i-nce of 

 inllainmatoi \ change-, or in tin ti--ne culture- b\ the more 

 nt method (i II ii-oii. ( arrel and liurrou-. \\hich i- -ur- 

 roimdetl b\ the i the inlerpretalioii of te-nlt- ari-in^ 



umlei einireh ne\\ -i i rroii ml i i i'j - and condition- as \et but little 

 under-tood. Both in the nie-entei\ and in li tie culture- 

 movements of the conne<ti\e ti lie cell- and even locomotion 

 have been observed. I no\\ add to the-e former re-ull- the record 

 of i he ob-ei \ a I ion of motion and locomotion in cell- under wholly 

 normal . ondition-. in animal- \\hich umleruent no operation 

 other than in -onie in-tance- tin- admini-t rat ion of chloretone, 

 and \\hich remaiiu-d ali\e. active and normal for -oinc time -ul>- 

 M'ljuent to the period of observation. 1 or example, the par- 

 ticular ti-h \\hich furni-hed the >ubject for I-'I'L;. I \\a- retnnu-d 

 to -ea \\aierand remained acti\el\ -\\immiiiL; tor i \\ o da\-; he 

 could ha\ e been kept much I- inger. 



l-'or the ojiportunit\ of pur-uinv; thi- -tud\ 1 am indebted 

 to the Marine Hiolo-ical Laboratory at Wood- Hole. M ISS. 



