Il6 VERA DANCHAKOFF AND S. M. SEIDLIN. 



digestion of the injected mass. The injected suspension of edestin 

 is a powerful chemotactic agent for both the granular leucocytes 

 and small lymphocytic cells. 



Secondarily a general reaction appears in the blood-forming 

 tissue of the kidney. It consists in intensive proliferative proc- 

 esses which seem to be in relation with the egress of small lympho- 

 cytes from this tissue. 



The lymphocytic cells emigrated from the vessels gather 

 around the injected mass, hypertrophy and gradually transform 

 into typical histiotopic wandering cells or lymphoid phagocytes. 

 They ingest large amounts of edestin granules and exercise a 

 digestive capacity. The digestive activity manifested by these 

 cells seems both to stabilize the newly acquired structure of the 

 phagocytes and to sharpen further their digestive power. 



The granular leucocytes though active in ingesting the edestin 

 granules do not seem to be capable of digesting them. These 

 cells, especially those containing edestin particles in their cyto- 

 plasm, are seen to succumb finally to the digestive activity of the 

 lymphatic phagocytes. There exist undoubtful indications that 

 some of the phagocytes have derived from the mesenchymal cells, 

 but their role cannot be easily determined in these experiments. 



Two days after injection all the edestin granules are found 

 within the phagocytes; seven days after injection all of the edestin 

 has disappeared. 



The digestive processes within the injected region not only 

 result in the formation of a generation of new eminently phago- 

 cytic cells, but seem to reflect secondarily upon the whole organ- 

 ism. Innumerable cells of the type of small lymphocytes are not 

 only transformed into lymphoid phagocytes, but these phagocytes 

 are soon found at a considerable distance from the region of 

 injection and part of them are probably distributed through the 

 blood current to more distant parts of the organism. 



BIBLIOGRAPHY. 

 i. Clark, E. R. 



'16 A Study of the Reaction of Mesenchyme Cells in the Tadpole's 

 Tail toward Injected Oil Globules. Anat. Rec., Vol. u, No. i, 

 August. 



