152 LEO LOEB. 



muscle takes place in the auto as well as in homoio graft. This is 

 the result of the injury caused by the process of transplantation 

 and the defective nourishment directly following the grafting. 

 But from about the sixth to the tenth day following transplan- 

 tation a much better, more complete recovery of the myxoid and 

 unstriated muscle tissue takes place in the auto- than in the homo- 

 iotransplant, and while subsequently in the autotransplant these 

 two tissues maintain themselves, in the homoiotransplant a grad- 

 ual substitution of the injured myxoid and muscle tissue by 

 fibrous tissue takes place sometime between the fourteenth and 

 twenty-fourth day. On this soil of fibrous tissue the epithelium 

 does not thrive so well as on the myxoid connective tissue of the 

 autotransplant ; it decreases therefore in size, and becomes lower ; 

 later it is again attacked by lymphocytes and thus gradually de- 

 stroyed. The lymphocytes though appear here somewhat later 

 than in the homoiotransplanted thyroid and kidney ; but as in the 

 case of the other organs their attack is mainly directed against 

 the epithelial tissue, although they do not leave entirely free some 

 of the other tissues. Again we find as the result of those ab- 

 normal substances which form after homoiotransplantation, we 

 may call these substances homoiotoxius an attraction of lympho- 

 cytes and an altered behavior of connective tissue cells. But in 

 addition we find in this case a very early injurious influence of 

 the hcmoiotoxins on two sensitive tissues, namely myxoid or pre- 

 deciduomatous and unstriated muscle tissue. They show the in- 

 jurious effect of the conditions prevailing in the strange host at 

 a time, when lymphocytes have not yet had a chance to play any 

 considerable part. How far these two tissues are injured directly 

 by an inadequate constitution of the body fluids of the host (by 

 the " homoiotoxins "), and how far the latter influence primarily 

 the vascular supply, the latter in turn influencing the life of the 

 myxoid and unstriated muscle tissue, is uncertain at present. It 

 is however more probable that their destruction is primarily due 

 to the inadequacy of the body fluids rather than to an insufficient 

 vascular supply, which latter would then be the direct conse- 

 quence of the lack of adaptation between body fluids and trans- 

 planted tissue. There is another point of interest in the trans- 

 plantation of the uterus. We find that the primary transforma- 



