460 M. R. CLARE. 



should suggest types of investigation which are most likely to 

 contribute to an understanding of metabolism in Drosophila 

 melanogaster. 



It has been shown that a close approach to a knowledge of 

 metabolism in Drosophila pupae cannot be made if sole depend- 

 ence is placed on weight of respiring tissues as a guide. In a 

 very rough way, pupal weights show a correspondence with the 

 trends of metabolic rates, but, for particular matings, especially 

 when the larvae are maintained at lower temperatures, the 

 correspondence is largely lost. It has also been shown that rates 

 of oxygen consumption are very irregular and vary in a manner 

 highly suggestive of the influence of environmental agencies. 

 The not infrequently pronounced elevations above the general 

 level of metabolism lend support to the conclusion that the 

 metabolic rates for comparable samples of respiring tissue are 

 not necessarily fixed within narrow limits. Finally, it has proved 

 impossible to find a metabolic difference between the sexes or to 

 detect any difference in metabolism between inbred and non- 

 inbred stocks. 



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