Il8 R. KUDO. 



chromatin granules appearing to accumulate in a peripheral 

 layer (Fig. I, /?) The nucleus seems to undergo a direct division 

 and forms two daughter nuclei (Fig. i,i). The cytoplasmic body 

 of the schizont grows at the same time, becomes constricted into 

 two parts (Fig. I, i) and finally divides into two uninucleated 

 bodies. This division is most probably repeated in the early 

 phases of the infection, the forms shown in Fig. I, /, being mainly 

 of this kind. The nucleus may sometimes show a karyosome in 

 it; in such a nucleus the division seems to be initiated by that of 

 the karyosome. Frequently the cytoplasm does not follow the 

 nuclear division and the nuclei divide again (Fig. i, k). This is 

 usually followed by an elongation of the body and by a division 

 into two portions in each of which two nuclei are to be found 

 (Fig. i,*). 



Another type of division noticed was initiated by a great 

 increase in the size of the nucleus (Fig. i, j). The nucleus 

 becomes vesicular and exhibits a distinct karyosome near its 

 center from which achromatic threads radiate toward the 

 periphery. The cytoplasm contains two or more deeply staining 

 grains. The karyosome divides into two and a' septum is 

 formed between them while the deeply staining grains become 

 condensed at the opposite ends. This nuclear division does not 

 seem to be followed by immediate division of the cytoplasm. 



As the result of these schizogonic divisions, stages such as 

 shown in Fig. i, m, are produced. These are the only forms 

 which were observed even in the larvae examined four days after 

 feeding on the material. As the time after feeding elapsed, 

 the number of the various stages of the schizonts present in the 

 fat body increased, although in none of the larvae stages of 

 sporogony were observed. It may be of interest to note that 

 in one of the larvae fixed four days after the experiment was 

 started, the follicular epithelium of the ovary on the left side of 

 the host body was greatly replaced by these stages described here, 

 although the young ova seemed to be free from the parasite. 



SCHIZOGONY. 



Young forms found in the adipose tissue of naturally infected 

 larvae are represented by Fig. 2, a. They are comparable with 

 the late stages noted in the experimentally infected larva: in that 



