460 ELECTRO-PHYSIOLOGY CHAP, iv 



substance, arising under the influence of current, as to the 

 nature of which nothing definite can at present be predicated. 

 But while the changes consequent upon closure of the current 

 are directly engendered by the latter, the opening effects relate 

 essentially to phenomena of reaction in the altered muscle- 

 substance itself, and not merely the anodic opening excitation, 

 but the kathodic opening inhibition also, must be interpreted 

 in this sense. 



