176 L. J. COLE AND W. A. LIPPINCOTT. 



approximately 2.5 cm. in diameter appears to be a subcapsular 

 haemorrhage. A large central lake appears to be made up almost 

 entirely of large vascular channels and to be the site of extensive 

 haemorrhage. The proximal lakes show numerous large vas- 

 cular channels separated by tissue, in the main rather translucent 

 and glistening, but showing numerous small opaque areas. 



"Microscopical Study. Sections from the larger lake show 

 many large channels filled with blood. Some of the larger of 

 these are thrombosed; some of the thrombi are comparatively 

 recent, others are old and show deposits of calcium salts in the 

 hyaline material. The intervening tissue, which is small in 

 amount, is necrotic. 



"Sections from the proximal lakes show numerous vascular 

 channels, few of which are thrombosed. These channels are 

 separated by a considerable amount of connective tissue, which 

 is in most places cellular, and apparently of recent growth. 

 This tissue is in many places thickly infiltrated with lymphocytes 

 and with numerous cells with eosinophilic granulation. There 

 are recent small haemorrhages into the interstitial tissue and 

 evidence of old haemorrhages, in the presence of haemosiderin 

 masses. 



"In addition to the changes described there are throughout 

 the intervascular tissue in these sections alveoli of various sizes, 

 but usually small, solidly filled with cells of an epithelial (or 

 endothelial) appearance. The cells vary much in size and ap- 

 pearance. The average cell has a nucleus of from 12 /JL to 15 M 

 in diameter with distinct nucleolus and fairly heavy chromatin 

 network. The protoplasm is abundant, granular, and shows a 

 tendency to fatty degeneration. The cell outline varies. In 

 some alveoli they are almost columnar, in others spindle-shaped, 

 and in others their outline is difficult to determine as the cells are 

 closely united into sheets or columns resembling a syncytium. 

 While most of the vascular channels are lined by a delicate 

 flattened endothelium, in some places they have a lining of high 

 irregular cells of the character seen in the intervening alveoli. 

 One further gains the impression that it is from such layers that 

 the cells of the alveoli are derived. No evidence of ovarian 

 structure is found in the sections. 



