ICO LEO LOEB. 



when examined. Only one ovary was examined microscopically. 

 Small and small-medium good follicles; some granulosa degenera- 

 tion in other small-medium follicles. Various stages of connec- 

 tive tissue atresia; especially many follicles in the last stages of 

 connective tissue atresia, much interstitial gland. No corpus 

 luteum present. Uterus showed low cuboidal-cylindrical epi- 

 thelium of surface and glands without mitoses; fibrillar mucosa. 

 The mammary gland consisted of dense fibrous tissue with a few 

 ducts and acini; acini with cuboidal epithelium and without 

 colloid in the lumen. At places the stroma was somewhat 

 more cellular. In this case we can be sure that the ovaries 

 were hypotypical, although only one ovary had been examined. 

 The condition of the uterus makes it certain that a recent 

 ovulation had not taken place. The animal has been markedly 

 affected by the underfeeding, it was in a dying condition at the 

 end of the experiment. 



Guinea Pig No. 5. The animal was found dead. Hypotypical 

 ovaries of the second order. Some medium follicles with granu- 

 losa degeneration. Two retrogressing small vacuolar corpora 

 lutea with thick vessels. Uterus is hypotypical. In this case 

 ovulation had been delayed. 



Guinea Pig No. 6. Examined in a dying condition. Hypo- 

 typical ovaries of the second order. Some almost medium 

 follicles with a thin wall of granulosa. In follicles of almost 

 medium size some granulosa degeneration. No corpus luteum or 

 remnant of a corpus luteum visible. Uterus hypotypical. 



Guinea Pig No. 7. Found dead. No noticeable postmortem 

 changes. Hypotypical ovaries of the first order. Small de- 

 generating corpora lutea with vacuolar cells and thick vessels. 

 Uterus hypotypical. In this case a new ovulation had not yet 

 taken place, although the corpus luteum of the preceding period 

 was degenerating. The loss of weight in this case had been rapid. 



Guinea Pig No. 8. Found dying. Hypotypical ovaries of the 

 second order. There is present a retrogressing small corpus 

 luteum with vacuolar cells. Uterus hypotypical. Mammary 

 gland shows dense fibrous tissue and small gland ducts without 

 mitoses. Ovulation was delayed. 



Guinea Pig No. 10. Found dead, slight postmortem changes. 



