IO4 LEO LOEB. 



mitoses in surface epithelium, nowhere else; fibrillar mucosa. 

 Mammary gland: Large gland, with acini of various sizes, often 

 filled with colloid material. Fibrous or fibrillar stroma, with 

 small nuclei. Some epithelial cells with vacuoles, indicating 

 slight secretory activity. In this case there is perhaps present 

 a beginning of a change in the direction toward the development 

 of hypotypical ovaries; but as yet the ovaries have not reached 

 this condition. The state of the mammary gland and possibly 

 of the ovaries suggests that an abortion has taken place a rela- 

 tively short time previous to the examination. The large vacuo- 

 lar corpora lutea with thick vessels, as well as the condition of 

 the mammary gland, which shows signs of secretion, suggest such 

 a conclusion. 



Guinea Pig No. III. Ovaries: Young corpora lutea. Loose 

 central connective tissue fills the cavity. Atretic yellow vacuolar 

 body with thick vessels (remnant of corpus luteum). Good 

 small, medium and almost large follicles. No large follicles, but 

 a few almost large follicles with granulosa degeneration. A 

 number of small-medium or medium follicles lost their granulosa 

 through a gradual process of solution and form cysts in which 

 the egg is lying free. In other degenerating follicles of this kind 

 connective tissue grows into the cavity. Many follicles in last 

 stage of connective tissue atresia. Mammary gland: Good sized, 

 acini with cuboidal epithelium, fibrous stroma. No mitoses. 

 The ovaries are not yet hypotypical, but the condition of the 

 smaller follicles indicates a beginning change in this direction. 



Guinea Pig No. IV. Nine days after the beginning of the 

 experiment the animal was offered a larger quantity of food, but 

 refused to eat it. One day later it was found in a very weak 

 condition and it was examined. Ovaries: Corpora lutea vacuolar, 

 with thick vessels; they show beginning degeneration, atretic 

 yellow bodies (the remnants of degenerated corpora lutea). 

 Good small and small-medium follicles. Large follicles show 

 granulosa degeneration. Well preserved large follicles are not 

 present. Follicles in various stages of connective tissue atresia. 

 Uterus: Relatively low surface epithelium. Similar epithelium 

 in glands. Fibrillar mucosa without mitoses. Mammary gland: 

 small gland in a resting condition with marked development of 



