94 LEO LOEB. 



small and small-medium good follicles. In the latter follicles a 

 slow solution of granulosa sets in. We see some follicles of 

 almost medium size without granulosa, but as yet without 

 connective tissue ingrowth. Follicles in various stages of con- 

 nective tissue atresia, especially numerous follicles in the last 

 stages of connective tissue atresia with relative prominence of 

 the theca interna. A small yellow fibrous body, the remnant 

 of an atretic corpus luteum is present. 



Uterus thin with the usual relatively low epithelium and small 

 glands and fibrillar mucosa. In this case after degeneration of 

 the corpus luteum of the former period, a new ovulation failed 

 to take place and the follicles did not grow to normal size. A 

 hypotypical ovary resulted. 



Guinea Pig C. Examined fourteen days after beginning of 

 feeding experiment; had lost 36 per cent, of its weight. Ovaries 

 small, living corpora lutea with small center of fibrous tissue. 

 There is perhaps one mitosis in a Lutein cell. In addition there 

 are fibrous, yellow bodies, the remnants of degenerated corpora 

 lutea. Small and small-medium good follicles. Medium fol- 

 licles show slow granulosa degeneration. The ingrowth of con- 

 nective tissue into the follicles is probably somewhat delayed; 

 there are a number of follicles with loss of granulosa and as yet 

 without ingrowth of connective tissue. Various stages of con- 

 nective tissue atresia of follicles are seen. Atretic follicles in 

 the last stage of atresia and with a large mantle of theca interna 

 are frequent. Uterus shows the same character as in the other 

 animals; relatively low epithelium, small glands, fibrillar mucosa. 

 Mitoses nowhere visible. 



We may assume that in this case the last ovulation took place 

 very soon after the beginning of the feeding experiment. No 

 trace of proliferation was visible in the uterine mucosa. This 

 indicates that at least ten days had elapsed since the last ovula- 

 tion, a conclusion in accordance with the character of the corpora 

 lutea. The follicles instead of growing to normal size after 

 ovulation, remained small and underwent premature atresia. 



Guinea Pig D. Examined fourteen days after beginning of 

 feeding experiment; had lost 34 per cent, of its weight. Ovaries 

 with small and small-medium good follicles. In the latter slow 



