EXPERIMENTAL PRODUCTION OF HYPOTYPICAL OVARIES. IOQ 



From the results of this series, we may draw the following 

 conclusions: Of the seven animals which were subjected to the 

 low diet, 3 showed hypotypical ovaries of the first order; 3 

 showed hypotypical ovaries of the second order. In all of these 

 cases ovulation had been prevented. In one case, the ovaries were 

 not hypotypical, although the loss in weight had been just as 

 considerable as in other cases. In this case, however, matura- 

 tion of follicles and ovulation failed to take place. If we inquire 

 into the condition responsible for these differences in the behavior 

 of different animals, we may suggest that it depends in all 

 probability on differences in the general effect of underfeeding 

 on the animals. Those animals that were alive at the end of 

 the experiment showed a less far-going hypotypical condition 

 than those that had just died at the time of examination. This 

 series shows furthermore that a hypotypical condition may be 

 produced even in a relatively old guinea pig with a considerable 

 initial weight, provided there is a considerable loss of weight 

 extending over a relatively long period of time and a marked 

 influence in the general condition of the animal. If, on the other 

 hand, an animal with a considerable initial weight is less affected 

 generally and its strength is better preserved, throughout the 

 experiment, merely maturation of the follicles and ovulation are 

 prevented from taking place, but a hypotypical condition is not 

 produced. In all those cases in which the ovaries are hypotypical 

 the uterus is thin and shows the resting condition found also in 

 the other series. In this series the loss of weight of the underfed 

 guinea pigs was more considerable than in the other series and the 

 experiment extended over a longer period of time. In the two 

 control animals a hypotypical condition of the ovaries was not 

 found. In one of these the cycle in ovaries and uterus took its 

 normal course; in the other, a loss of weight had occurred, the 

 cause of which remained obscure. While in this case the ovaries 

 do not show a hypotypical condition, some retardation in the 

 development of the follicles had occurred. 



CONCLUSIONS. 



We used in our experiments altogether thirty-four guinea pigs, 

 eight of which served as controls, while twenty-six were sub- 



