THE CONCRESCENCE OF FOLLICLES IN THE 

 HYPOTYPICAL OVARY. 1 



LEO LOEB. 



In a preceding paper we have shown that lack of sufficient 

 nourishment is the cause of a hypotypical condition of the ovaries. 

 In one guinea pig we found in addition to the hypotypical 

 condition another peculiarity of the ovaries, which is of consider- 

 able interest and which deserves a special description. In con- 

 nection with the facts reported in the preceding paper it leads 

 to some interesting conclusions as to the effect of underfeeding 

 on the development of the ovarian stroma, and on the develop- 

 ment of what in the guinea pig in certain respects corresponds to 

 the interstitial gland of the rabbit and it may throw light on 

 the origin of follicles containing more than one egg. 



Female guinea pig No. 383 was obtained from Iowa. On 

 January 12, 1917, it weighed 475 grams; on that date both lobes 

 of the thyroid of this animal were removed. One thyroid lobe 

 from another guinea pig, obtained from a different breeder and 

 weighing 380 grams, was transplanted into the subcutaneous 

 tissue of guinea pig No. 383. The transplanted thyroid was 

 removed for microscopic study seventeen days later, January 29. 

 At that time the guinea pig weighed 322 grams ; it had therefore 

 lost 32 per cent, of its original weight in a period of seventeen 

 days. The transplanted thyroid was on the whole in a very 

 good condition; we shall refer to this aspect of our findings in 

 another connection. Here we are especially concerned with the 

 condition of the sexual organs. The uterus shows low or medium 

 cylindrical epithelium of the surface and glands with a very small 

 number of mitoses in the surface epithelium. The mucosa is 

 thin and fibrillar but very hyperemic. In the lumen of the uterus 

 there are some erythrocytes. The ovaries are markedly hypo- 

 typical. They contain several atretic yellow bodies, the rem- 



1 From the Department of Comparative Pathology, Washington University, 

 Medical School, St. Louis. 



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