CONCRESCENCE OF FOLLICLES IN HYPOTYPICAL OVARY. 189 



differentiate microscopically the ovaries of this animal from 

 those of other guinea pigs. There occurs in these ovaries a 

 considerable number of follicles with two, three or even more eggs. 

 We see in the most peripheral zone of the ovary two well preserved 

 eggs of about the same size, but one slightly pressing upon the 

 other and both surrounded by a single layer of granulosa cells. 

 Somewhat further away from the tunica albuginea we see small 

 follicles with two eggs of the same size, separated only imperfectly 

 by a few flat granulosa cells. At other places we see follicles of 

 small to medium size with a cavity. At the end of the cavity 

 directed toward the center of the ovary there is a relatively 

 large, well-preserved egg, surrounded by several rows of granulosa 

 cells. At the side of the follicle directed toward the periphery 

 of the ovary there is a very small, but well-preserved egg, in 

 an earlier stage of development, surrounded by only one layer 

 of granulosa cells. Here we have a combination of a primordial 

 and of a small Graafian follicle. In other cases we see a small 

 egg of a primordial follicle, pushing its way through the granulosa 

 of the somewhat larger follicle and just reaching the cavity with 

 the outer pole; the most frequent orientation of the two eggs 

 is as follows: The larger one, surrounded by several rows of 

 granulosa cells, is placed at the central pole of the cavity and 

 the smaller one more toward the peripheral pole. But occa- 

 sionally the order may be reversed, or the small egg may be at 

 the lateral aspect of the follicle. In one case we found the egg 

 of the primordial follicle in the suspensory ligament of the granu- 

 losa of the larger follicle. In still other cases we find a combina- 

 tion of a small egg at an early stage of its development, sur- 

 rounded by one row of granulosa cells, the whole corresponding 

 to a primordial follicle in the cavity of a small to medium follicle 

 in which the granulosa and egg have already undergone degenera- 

 tive changes. The degenerating ovum may still be surrounded 

 by granulosa cells or the granulosa cells may have been dis- 

 solved. In other cases we find in a follicle of small to medium 

 size two well developed eggs, both surrounded by several layers 

 of granulosa cells. Similar combinations we find in follicles with 

 three eggs. There may be combined a degenerated egg, a rela- 

 tively large, preserved egg surrounded by several layers of granu- 



