Effects of Ovarian Extracts 



143 



generally to cause an increase of force and rate of the rhythmic movements, 

 and increased tone of the muscle. With hilurn ovarii the effect is inhibition 



FIG. 97. Effect of addition of extract of hilum ovarii of cow to Locke's solution in which a 

 cornu of uterus of rat was suspended. Notice the cessation of rhythmic contractions and 

 diminution of tone. 



FIG. 98. Effect of addition of liquor folliculi of cow to Locke's solution in which a cornu of rat 

 uterus was suspended. Notice the increase of tone with cessation of rhythmic movements. 

 At "Locke" the liquor folliculi was removed and Locke's solution substituted. 



with marked diminution of tone. Rarely this inhibitory effect rather than 

 increased contraction is obtained with the other extracts. 



It appears probable from these observations that ovarian extracts con- 

 tain two different kinds of autacoid acting upon plain muscle, especially upon 



