Clinical Evidence regarding Functions of Pituitary 107 

 ferieures et cephalique " a marked non-congenital enlargement of the 



FIG. 73. Case of acromegaly, front and side view. (From Klebs and Fritsche.) The 

 illustration sliows the enlarged hands, feet, and joints, the massive elongated face and 

 thick lips, the dorsal curvature (kyphosis), the apathetic look. 



B 



c 



D 



FIG. 74. Four photographs of the same person showing the gradual development of the 

 facial appearance characteristic of the acromegalic. (Gushing. ) 



A, at 24 years of age (prior to the commencement of the disease) ; B, at 29 (onset of disease) ; 



C, at 37 ; D, at 42 years of age. 



limbs and head. The hands (fig. 75), feet, and face are especially hyper- 

 trophied, and X-ray photographs show a typical mushrooming of the ungual 



