THE CHEMICAL CHANGES IN MUSCLE 245 



during the stimulation of the muscle. SchondorfE has shown that if 

 excised muscle be kept alive by perfusion of defibrinated blood, its 

 activity is associated with slightly increased formation of ammonia. 

 The formation of ammonia is, however, the natural mode of protection 

 of the whole organism against acid poisoning, and it seems quite 

 probable that in SchondorfE 's experiments the ammonia formation 

 was simply a secondary result of the lactic acid formation and not a 

 direct expression of the metabolism of the active muscle. 



