4 LEO LOEU. 



in large numbers through the connective tissue of the mucosa, 

 through the epithelium and the gland ducts. Under their influ- 

 ence much of the surface epithelium has been destroyed and 

 even the epithelium of the gland ducts has been loosened. 



Soon after parturition the guinea-pig is ready to copulate. 

 At this time the mucosa is papillary and low. The muscle tissue 

 lies at a number of places near the surface epithelium; the glands 

 are therefore short; the epithelium is cuboidal or cylindrical, at 

 some places high and with much cytoplasm ; the vesicular nuclei 

 are often at the base of the cell. Sometimes there are vacuoles 

 in the epithelial cells. Mitoses are extremely rare in the epi- 

 thelium; the gland cells are small and without mitoses. The 

 connective tissue in the mucosa is somewhat edematous; it 

 forms only a small layer; the nuclei are not large, rather densely 

 packed; mitoses are not visible. At some places the epithelium 

 is absent and coagulated blood with polynuclear leucocytes 

 covers the surface. The muscle tissue is turgid and some plas- 

 modia are visible around the vessels of the muscular coat. The 

 condition of the surface epithelium is here apparently similar to 

 the epithelium during the period of heat. 



From twelve to tiventy-four hours after copulation. This period 

 is marked through the great number of polynuclear leucocytes 

 seen in the lumen of the uterus, in the lumen of the glands and 

 especially in the upper ducts of the glands. There may be also 

 present abscess-like collections of polynuclear leucocytes in the 

 connective tissue of the mucosa. They may raise up the surface 

 epithelium from the underlying connective tissue at some places; 

 at other places they rarify and almost destroy the epithelial cells. 

 We may still see twelve hours after copulation the high cylin- 

 drical shape of these cells. The glands are short and they^do not 

 show much branching; the gland ducts still show a lining of 

 cylindrical cells; some gland-lumina are dilated through masses 

 of leucocytes and the leucocytes may exert such a pressure on 

 the walls of the glands that the epithelium becomes flat. Mitoses 

 are seen at this period. 



From one to four days after copulation. Two days, five and a 

 half hours, and two days, seven hours after copulation, the 

 epithelium of the surface and of the gland ducts is cylindrical 



