14 LEO LOEB. 



angles to the long axis of the connective tissue cells; but mitoses 

 are no longer present and some cells disintegrate in the upper 

 part of the mucosa. 



Nine days after heat. There is as yet not any, or very little 

 granulosa degeneration in the large follicles; occasionally there 

 may be more extensive degeneration of the granulosa and a few 

 exceptional follicles may show an early stage of connective tissue 

 atresia; in some ovaries all the large follicles are still well pre- 

 served. The follicles which six to eight days after the former 

 period of heat were in the last stage of connective tissue atresia, 

 shrink under the influence of the pressure of the growing follicles 

 and corpora lutea. 



The uterine epithelium of the surface is low to medium-sized 

 cylindrical, a few vacuoles may be present in the epithelium, the 

 gland epithelium is low cylindrical. The connective tissue of the 

 mucosa shows still vesicular nuclei and vacuoles in the cells, but 

 it is being somewhat compressed. There are no mitoses present 

 in the epithelium or in the connective tissue. 



Eleven days after heat. We find good small, medium-sized and 

 large follicles, some large follicles show granulosa degeneration 

 or connective tissue in growth. The follicles which were formerly 

 in the last stage of connective tissue atresia begin to disappear 

 more and more; there are still the remains of the membranae 

 pellucidse, surrrounded by some very small compressed nuclei. 

 The corpora lutea are in a good condition. Mature follicles 

 appear again in the ovaries. 



The epithelium of surface and gland ducts of the uterus is 

 cyclindrical, of medium size. The gland fundi are smaller. No 

 mitoses are seen; some mononuclear cells may be present, but 

 neither vacuoles nor chromatin particles; there is still some rem- 

 nant of the cell layer in the mucosa, but it is becoming smaller and 

 more fibrillar; only an exceptional mitosis can be found in the 

 connective tissue. 



We find, therefore, active cell proliferation in the connective tissue 

 of the mucosa from the fourth to the seventh day after the last ovu- 

 lation. Approximately five days after ovulation the mitoses dis- 

 appear also in the gland fundi. From the sixth to the twelfth day 

 after ovulation, the epithelium of the uterine mucosa is without 

 mitoses. Then they begin to reappear. 



