18 LEO LOEB. 



at the time of the examination; in the sixth case the guinea-pig 

 had been in a very weak condition and in the ovaries no good 

 large or mature follicles, but some large follicles in granulosa 

 degeneration, were found. In the seventh case the corpora 

 lutea had been burnt instead of excised with the scissors. As 

 we saw previously, the burning out of the corpora lutea injures 

 the ovaries and prevents in many cases an early ovulation. In 

 four cases in which the uterus had been cut, and in one other 

 case, one ovary had been excised previously. 



The uterus in these cases in which ovulation had not been 

 hastened through extirpation of the corpora lutea was found to 

 be as follows: 



(1) No. 642. Three days after copulation extirpate corpora 

 lutea examination. Sixteen days after the previous copulation 

 the animal was in a weak condition. In the ovaries there was no 

 good large or mature follicle, there were some large follicles with 

 granulosa degeneration. The surface epithelium of the uterus 

 was cuboidal ; it contained some vacuoles with chromatin particles ; 

 there were very few mitoses present. The uterine glands were 

 cuboidal to cylindrical and showed no mitoses. The connective 

 tissue was fibrillar, the nuclei near the surface epithelium were 

 more numerous; no mitoses were present in the connective tissue. 



(2) No. 693. Seven days after the previous copulation ex- 

 tirpate the corpora lutea; ten days later examination. Abortion 

 had taken place. The ovaries showed small and large good 

 follicles and large follicles with granulosa degeneration; mature 

 follicles were present. There were also follicles in various stages 

 of connective tissue atresia. 



The surface epithelium of the uterus was cuboidal to cylindrical 

 and showed many mitoses; the glands were small and without 

 mitoses; there was fibrillar connective tissue; where abortion 

 had taken place, the connective tissue was hypersemic, edematous 

 and there were many polynuclears in the vessels. 



(4) No. 300. Twenty-three hours after copulation extirpate 

 left ovary; six days later make incision into the uterus; seventeen 

 days after copulation, examine the uterus. In the remaining 

 ovary of the animal which was about four months old, no corpus 

 luteum and only small and small-medium sized good follicles 



