Vol. XXVII. July, 1914. No. i 



BIOLOGICAL BULLETIN 



THE CORRELATION BETWEEN THE CYCLIC CHANGES 

 IN THE UTERUS AND THE OVARIES IN THE 



GUINEA-PIG. 1 



LEO LOEB. 



TABLE OF CONTENTS. 



I. The Cyclic Changes in the Uterus of Guinea-pigs in which Copulation 



Takes Place i 



II. The Sexual Cycle of Uterus and Ovaries in Guinea-pigs in which Heat 



had been Observed, but Copulation Prevented 9 



III. The Effect of Extirpation of the Corpora Lutea on the Cyclic Changes 



in the Uterus 17 



IV. The Uterus of Pregnant Guinea-pigs in which after Excision of the 



Corpora Lutea a New Ovulation has Taken Place 22 



V. The Influence of Extirpation of the Corpora Lutea on the Duration of 



the Cyclic Period 31 



VI. The Signs of Heat in the Guinea-pig 32 



VII. Effect of Extirpation of the Ovaries on the Cyclic Changes in the Uterus. 34 



VIII. Summary 40 



In former papers we analyzed the production of the maternal 

 placenta and of the experimental placenta; we followed the cyclic 

 changes in the mammalian ovaries and partly analyzed the 

 factors determining the first step in these changes, namely 

 ovulation. In this paper we shall describe more in detail the 

 cyclic changes in the uterine mucosa of the guinea-pig and 

 correlate these changes with those in the ovaries. We shall 

 analyze the effect of pregnancy, of the corpora lutea and other 

 parts of the ovaries on those changes. 



I. THE CYCLIC CHANGES IN THE UTERUS OF GUINEA-PIGS IN 



WHICH COPULATION TAKES PLACE. 



At the period of heat and soon after copulation. In the uterus the 

 surface epithelium and the gland ducts show high cylindrical epi- 



1 From the Department of Pathology, Barnard Free Skin and Cancer Hospital, 

 St. Louis, Mo. 



