6 LEO LOEB. 



connective tissue in wounds, the vessels running at right angles 

 to the bundles of connective tissue cells. The enlargment of 

 the connective tissue causes a drawing out of the gland ducts 

 and now mitoses appear also in the gland fundi, perhaps as a 

 result of the pull exerted on the gland ducts. Some leucocytes 

 migrate through the mucosa and epithelium. 



About four days after copulation, or soon afterwards, the surface 

 epithelium has become lower; it is either cuboidal or cylindrical, 

 of medium height. No mitoses are present in the surface epi- 

 thelium or in the cuboidal or low cylindrical gland ducts. The 

 cells in the fundi of the glands are cylindrical and there are very 

 many mitoses present. The mitoses migrate therefore gradually 

 from the surface into the gland fundi, and concomitantly with 

 the decrease in mitoses we find a decrease in the size and shape 

 of the epithelial cells of the surface and gland ducts. In the 

 connective tissue there is now a decided increase in the number of 

 mitoses especially in cells near the surface and gland epithelium. 

 The connective tissue cells themselves have vesicular nuclei and 

 form fibrillar processes. Between the gland fundi the inter- 

 cellular fibrils are more marked; the number of nuclei is smaller 

 and there are less mitoses present. The tissue may, however, 

 be edematous. The mitoses are mainly present in the fibro- 

 blasts, but there are some mitoses also in endothelial cells of 

 capillaries. The proliferation takes place principally in the 

 fibroblasts and the predecidual cells do not originate in the endo- 

 thelium of the blood vessels. The vessels are often running 

 directly towards the surface epithelium and at right angles to the 

 direction of the connective tissue cells. There are occasionally 

 some polynuclears present in alveoli of glands. 



Six to eight days after copulation. Six days, and on the seventh 

 day after copulation, the surface and the gland epithelium is 

 cuboidal low, or medium cylindrical. The gland ducts are 

 drawn out. In the glands there may still be some higher cylin- 

 drical epithelial cells left; nowhere are mitoses present in the 

 epithelium. There are mitoses in the connective tissue under- 

 neath the surface epithelium and between the gland ducts. The 

 arrangement is the one typical for regenerating connective 

 tissue, the vessels running at right angles to the layers of the 



