CYCLIC CHANGES IN UTERUS AND OVARIES. 7 



connective tissue. Below the epithelium there are layers of 

 densely packed large vesicular nuclei; the cells are often free, 

 not enveloped by fibrils. The number of mitoses varies some- 

 what at different places. The gland fundi are surrounded by 

 edematous connective tissue and between the gland fundi we 

 find fibrillar connective tissue. The cellular connective tissue 

 separates the gland fundi from the surface epithelium. Some 

 polynuclear leucocytes are in the mucosa; we see here some dis- 

 integrating cells; it is possible that they are mainly polynuclear 

 leucocytes. 



Seven days, and on the first half of the eighth day after copu- 

 lation, the surface epithelium is cuboidal or low-medium cylin- 

 drical; at a few places it is somewhat higher with vacuoles in the 

 outer part of the cells; the nuclei are small vesicular. Usually 

 no mitoses are present, but in one piece a few mitoses could be 

 seen. 



The epithelium of the glands is cuboidal or low cylindrical; the 

 glands are drawn out. In one piece there are still a number of 

 mitoses in the gland fundi, although the gland cells are here 

 cuboidal. The structure of the connective tissue is similar to 

 that of the previous period. There are mitoses present in the 

 cell layer but they are not quite as frequent as before. The cell 

 layer consists of round, relatively small cells with many capillaries 

 with narrow endothelium. There is some hyperemia present. 

 At other places the nuclei in the cell layer are round vesicular, 

 and the cytoplasm of the neighboring cells is connected by 

 bridges. 



Eight days, eight hours, after copulation, the structure of the 

 surface epithelium and glands is similar to the previous period. 

 The epithelial cells are low. No mitoses are present. The glands 

 are not very large and contain a relatively small number of coils. 

 There is still some cell layer present under the surface epithelium; 

 the vesicular nuclei are compressed and a number of nuclei under 

 the epithelium disintegrate, perhaps the nuclei of the proliferated 

 connective tissue layer. 



Eight to seventeen days after copulation. In order to prevent 

 pregnancy the tubes had been ligatured near the junction with 

 the uterus soon after copulation. 



