CYCLIC CHANGES IN UTERUS AND OVARIES. 21 



eighteen days after copulation. Four to five days before the 

 examination a new ovulation had taken place. The epithelium 

 of the surface was found cylindrical of medium height without 

 mitoses; the glands had the same epithelium; there were mitoses 

 present in the fundi of the glands. The connective tissue of the 

 mucosa showed a layer of vesicular nuclei; it has a somewhat 

 myxoid character and contained many mitoses. This condition 

 of the uterus was in accordance with the time of the last ovu- 

 lation. 



(3) No. 773. Two days, eight hours after copulation, extirpate 

 the corpora lutea; sixteen days later examine uterus and ovaries. 

 Ovulation had taken place about seven days previously. Surface 

 epithelium and glands of uterus show cuboidal or cylindrical 

 epithelium of medium height; there are no mitoses present. In 

 the connective tissue there are still a large number of proliferated 

 cells, but only one mitosis is visible in the connective tissue 

 under the epithelium. This corresponds to the picture of the 

 uterus about seven to eight days after copulation. 



(4) No. 779. Six days after copulation extirpate corpora lutea. 

 Twelve days later examine uterus and ovaries. The ovaries 

 show that rupture had taken place about four days previously. 

 Surface epithelium and gland cells are cylindrical, relatively high, 

 there are many mitoses in the gland fundi; they are lacking 

 elsewhere in the epithelium. Small mononuclear cells migrate 

 through the epithelium; the connective tissue cells are swollen 

 and are densest under the surface epithelium; they form a 

 distinct cell-layer; there are mitoses in these connective tissue 

 cells. 



(5) No. 785. Six days, seventeen hours after copulation, ex- 

 tirpate corpora lutea; twelve days later examine uterus and 

 ovaries. The ovaries show that a new ovulation had taken place 

 five to six days previously. There was a cuboidal-cylindrical 

 surface epithelium of the uterus without mitoses. The epithelium 

 of the glands was somewhat higher and also without mitoses. 

 There is a cellular connective tissue under the epithelium with 

 mitoses; underneath the epithelium the nuclei are more densely 

 packed; somewhat further down the tissue is more edematous. 

 The glands and vessels run at right angles to the connective tissue 

 layer. 



