38 LEO LOEB. 



uterus mitoses were found. In one case mitoses were also found 

 in the myxoid connective tissue of the mucosa and in this case 

 mitoses in the glands were usually present at places in the 

 neighborhood where also the connective tissue showed mitoses. 

 In other cases, however, mitoses were only found in the surface 

 epithelium and glands, but not in the connective tissue. These 

 changes in the mucosa are in all probability to be interpreted as 

 regenerative in character, following the necrosis of the placen- 

 toma. 



We may, therefore, conclude that extirpation of the ovaries 

 does not prevent regenerative proliferation in the mucosa of 

 the uterus; furthermore that extirpation of the ovaries shortens 

 in all probability the life of the placentomata. 



In a further series incisions were made into the uterus six to 

 seven days after copulation; ten days later the ovaries were 

 extirpated, and after a further lapse of five days (fifteen days 

 after incising the uterus) the examination was made. In these 

 cases the ovaries were therefore extirpated at a still later period 

 and the examination was made at a somewhat earlier date after 

 castration. The placentomata were found to a great extent 

 necrotic; some smaller parts which were better nourished, near 

 the mucosa and around large blood vessels were usually still 

 alive; no mitoses were found in the living cells. Here again 

 we find proliferative processes in the surface epithelium and in 

 three out of five cases also in the gland ducts of the uterine 

 mucosa near the necrotic placentomata. The gland cells in 

 those ducts in which mitoses are found are higher. Even in the 

 connective tissue of the mucosa there may be a few mitoses in 

 the connective tissue cells or in the blood vessels. This mitotic 

 proliferation must in all probability again be interpreted as 

 regenerative in character. Castration does therefore not prevent 

 these regenerative changes in the mucosa of the uterus. 



In control experiments in which incisions were made into the 

 uterus vsix to eight days after copulation but in which the ovaries 

 were left intact, the placentomata were still alive thirteen days, 

 and in some cases partly alive eighteen and nineteen days after 

 the incisions had been made. In other cases they were entirely 

 necrotic eighteen to twenty-four days after incising the uterus. 



