26 LEO LOEB. 



o 



been filled with connective tissue. There were present small and 

 large good follicles. In a few large follicles there was just a begin- 

 ning of granulosa degeneration. There were many follicles in a 

 late stage of connective tissue degeneration. A new ovulation had 

 taken place about six to seven days previously (eleven to twelve 

 days after the previous copulation). The uterus on both sides 

 showed the absence of a cell layer and of mitoses in the con- 

 nective tissue which was fibrillar. The surface epithelium was 

 cuboidal or cuboidal-cylindrical, and contained a number of 

 mitoses. The glands showed low epithelium without mitoses. 



(9) No. 979. Three days, four hours after copulation excise 

 piece of right uterus. Six days, four hours after copulation 

 excise one corpus luteum in right ovary, extirpate the whole 

 left ovary (with two corpora lutea). Examination twelve days 

 later showed three pregnancies in the left horn. In the right 

 ovary three new corpora lutea had formed not quite three days pre- 

 viously, about fifteen and a half days after the previous copulation. 

 The remaining uterus on the right side showed cuboidal or low 

 cylindrical surface epithelium with a few vacuoles and some 

 mitoses. The glands show cylindrical shape and are at some 

 places higher and contain mitoses. At one place there is more 

 cellular connective tissue with some mitoses in the connective 

 tissue cells present. At this place there had evidently a cut 

 been made at the time of the first operation and it is probable 

 that the abnormality which we find here has been caused either 

 through this cut, or perhaps through an ovum that began to 

 penetrate here into the mucosa but did not continue to develop. 

 However that may be, the changes which we find at one place 

 in the mucosa do not correspond to the stage of the sexual cycle 

 in which the animal was at the time. 



(10) No. 987. Five days, nineteen hours after copulation, 

 extirpate right ovary with two corpora lutea, excise one corpus 

 luteum in the left ovary. Examination twelve days later showed 

 two pregnancies in the right horn, apparently none in the left. 

 But microscopic examination disclosed that at one place in the 

 left horn, the ovum had also inserted itself, caused the production 

 of a small decidua, but that the ovum had found difficulty in 

 developing, perhaps the decidual reaction being not strong 



