6 4 



FORMATION OF DEFENSIVE FERMENTS 



extraordinary property possessed by the animal or- 

 ganism of responding with certain typical symptoms 

 to a second injection of the same material as was used 

 in the first injection. A certain time elapses in the 

 case of a guinea-pig, about fifteen to twenty days 

 before this state is overcome. 



0,60 



0,70 



-0.60 



-o,w 



-0,30 



Hours 



3 V J 



FIG. 3. 



6 8 1O 15 2O 



{a} i c.c. serum. 



o'5 c.c. of a 10 per cent, silk-peptone solution. 

 5 c.c. normal salt solution. 



(b) i c.c. serum at a temperature of 60. 



o's c.c. of a 10 per cent, silk-peptone solution. 

 5 c.c. normal salt solution. 



(c) i c.c. serum. 



i c.c. of a i per cent, gelatine solution. 

 4'5 c.c. normal salt solution. 



Cramp can be observed within different groups of 

 muscles, as well as a sudden fall of temperature, 

 &c. Peptones also can be demonstrated in the blood 

 after reinjection of the original protein. Various 

 authors have supposed that anaphylaxy is directly 

 connected with the production of derivatives of pro- 

 teins, particularly peptones, without, however, having 



