84 FORMATION OF DEFENSIVE FERMENTS 



certain nucleo-proteids as well as nucleins, to excite 

 anaphylactic phenomena of a very specific character. 

 Experiments on guinea-pigs, which were made in 

 collaboration with Kashiwado, showed that a second 

 injection of the same substance as was used in the 

 first instance produced specific cramps of the muscles 

 of the neck and of the jaw. Moreover, an increased 

 peristalsis was regularly present, the animals ex- 

 creting faeces continuously. Symptoms of lameness 

 soon set in, and a marked fall of temperature always 

 took place. We injected, for instance, nucleo- 

 proteids, nuclein substances which had been obtained 

 from the thymus, and finally nucleo-proteids from the 

 blood corpuscles of a goose ; the reaction was in all 

 cases a strictly specific one. In the case of nucleic 

 acids we were unable to get definite results, and it 

 would appear that these cannot produce anaphylactic 

 phenomena. It may be that, in the nucleo-proteids 

 and in the nucleins, their albuminous components are 

 the deciding factor. A systematic study of the nuclear 

 structure of the various cells of the same individual 

 may enable us to determine the question, whether 

 albumens that are in harmony with the nucleus take 

 part in its construction, or whether the nucleus plays 

 a part, in the cellular metabolism, which is repeated 

 in an identical manner in the various cells of the same 

 individual. 



So long as purely chemical research is unable to 



