ii 4 TIIK PHYSIOLOGY OF REPRODUCTION 



them &8 syncitia from which Uth ova ami follicular epithelial cells 

 took origin. 



On tlie other hand. Kolliker b.-lieved that the follicle-cells arose 

 from the epithelium of the AVolilian body, while Foulis, 1 Schron, 2 

 Wendeler/' and Clark, 1 expressing the opinion that the follicle-cells 

 are derived from the mesohlast, have also dissented from this the 

 more usual view. ( 'lark, in support of his theory, has pointed out 

 that the cells which immediately surrnund the primordial follicles 

 are often spindle-shaped and similar in appearance to many of the 

 strorna cells, and further, that tin- primordial ova in the early stages 

 of development are often apparently in direct contact with 

 connective tissue which ohviously had been derived from the 

 embryonic mesohl 



Most authorities, however (including the more recent in- 

 vestigators). are of opinion that the follicular epithelial cells, in 

 common with the ova. are derived from the germinal epithelium. 

 Further, Miss I.ane-( 'laypoir"- has shown that the epithelioid 

 interstitial cells," which (in addition to the connective tissue and 

 plain muscle fibres) are contained in the ovarian stroma, in all 

 pro) lability arise also from the original germinal epithelium. This 

 has been confirmed by Miss M'llroy, 7 who states that the primordial 



1 Koiilis, "'I'll.- hcvelopmeiit of tin- i>v;i, etc.," ./>',: Aiit. mill 

 vol. xiii., : 



- S. In. 'ii. ll.-itrag /Hi Kenntni-s dci Anatomic und Physiologic des 

 itocks der Sauffetoiere," ///.//._/'. ///x.-/<.W<. /</., \ol. xii., I- 

 u.-ndelci. " Entwickelungsgeechichte und Physiologic der Eierstocke," 



Martin's />< l\r-ii'l, &:< "//</ .\Wv'/< r.x7/,.-/>-, Jjeipzig, 1*99. 



4 ('lark. "Tin- Origin, <o "\\tli, and Kate of the Corpus Luteuni," .///<//.< 

 y//-///- Hi>.<f,itnl /.'/-//.<, vol. vii., 



6 Lane Clav pon. "Un tin- < iri^in and Life Historv of the Interstitial Cells 

 ot tli.- Ovary of the KaM.it." Pnc. H;l. SoC^ I'.., \<-l. l'\\\ii., 1905. 



a ronijiarat i\ a oimt of tue intt-rst itial snK.-taiirc in the ovaries of 

 varion> Maniinals, with n-f.-i encefl to thr liti-rattirc. sec Frat-nkcl, " Vergieichende 

 Histolo^is,.},,. rntfisu'-hungen iil.fi da- N'orkoinincn driisiger Fonnationrn im 

 [ntentitiellen Eaeratocksgewebe," ^IreA. /'. '''///'>/-., \>1. l.\.\v., 1906. A<'-ording 



to Ain-fl and lioiiin intt-r.-titial r-<-lls an- not |>rf->'iit in tin- ovari-s of aniinaU 

 which ovnlati- >|ioiitaiifoii-ly, tin- roi|,u> liitcnni taking their plai-c. (Houin 

 and Aiii-t-1. "Sin h-s HOIMO| ( .-I.'> et la Signitit-atioii dt-s (llandes a Secivtion 

 IntrriK- d.- l'< Kaiif." ' '. It. 8oc. AW., vol. Ixvii., liM'.t.) Sec also < )'| )onoghne 

 "<)n th>- ( 'oi'jHira Lutea and tin- Interstitial Ti->ue of the (Ivarvjn Marsupials," 

 (Jii-tr. ./,-. Mir,-. Science, vol. l.\i., IlHo), and Cesa- liianehi " ( )>ser\ a/ione .sulla 

 strnttura sulla funzione del la cosidetto glandiola interst ix.iale dell' ovaia,'' 

 .I/---/'. /. /V.v., vol. iv., 1!X)7). The latter author -~ay- that there is an in\ei-e 

 relation l>et wren the si/e of the corpus liiteuin and the develo|nnent of tin- 

 interstitial .-ells in th- varion- >|..-ie-- of Maniinals; also that in hibernating 

 animals the interstitial cells are 

 during summer and 

 num.' - 



lles <h- l'< ivarie de> ('ln-iropt.'re>." .I/-./,. ,/- /!,,,/.. \-,,\. xx\., ]!U! ; and 

 Rasmii.-sen. ('vrlic Changes in the Interstitial Cells, etc.," A'/,//.,,/-//,, ,/,///. 

 vol. ii.. \'.*\^. B t note, p. 1 L'(. 



" .M'llroy, "Thi- 1 )ev i-lopment of the ( lei m-( 'ells in the Mammalian Ovary," 

 /'/*. lin,/. Soe. i'.ili".. v..l. \\\i., lf>10. 



n t- varon- >|..-e-- o aniinas; aso tat n ernatng 



titial cells are poorly de\..|op-d during the winter sleep, hut 



nd particularly at the time of sexual activity thev are \er\- 



See alK> AthiM, M Becherches BUT lea Oelloles Inter- 



