122 THE PHYSIOLOGY OF REPRODUCTION 



According to Walsh ' the growth energy of the granulosa cells in 

 the guinea-pig is slow in small follicles ; then a gradual rise takes 

 place until the follicle attains medium size ; later there is a gradual 

 fall in growth energy until in large follicles the proliferate power 

 sinks almost to zero as maturity is reached. 



The liquor folliculi begins to form in the developing rat's ovary 

 at al>out the ninth day of pregnancy.- Miss Lane-Claypon suggests 

 that the karyolytic changes which occur in the nuclei of the follicular 

 epithelial cells may have some connection with the origin of the 



Fi'.. :}">. Young human (Jraalian follicle. The cavity contains 



the liquor folliculi. (From Sellheim.) 



liquor. She states, however, that in the process of formation <f the 

 liquor folliculi in the adult ovary, the follicle-cells appear simply to 

 disintegrateand dissolve without showing the phenomenaof karyolysis. 

 On the other hand Ilonore.-" who has investigated the subject in the 



by O*Donoohu6 "Tin' Corpus Luteum, etc., and I'olyovular Follicles 

 in /t'l.t'/", ".<," A,"//. .I/-... vol. \li.. I'.ML'). I .en [xwb baa discussed tbe formation 



of plurioval follicles which he says may m inmate either hv connective tissue 

 failing to L:KI\V ln-t \v-en tin- <-^x* in an early sta.tre, 01- hv \eiysmall follicles 

 pusliini: their way into larger follicles. I'.oth nii-thods depend upon the 

 inactivity of the connective t issue, which is prokiKly due to underfeeding, ;is 

 LoeK h.-i^ shown ("The Concrescence of Follicles in the Efypotypical Ovarv." 

 /;,,,/. //-///., vol. \.\\iii.. I!tl7). 



1 \Valsh. The (o-owth of the <t\aiian Follicle of the ( oiinea-Pig. under 

 Normal and Pathological Conditions." .A., //-. /;'.,,,. .I/../.. \,,1. x\vi., I!)I7. 

 ie-( 'laypoM. /'. ,-il. 



3 Honorc, "Recherches sur 1'Ovarie du L-i])in," .1/v/,. ,!, JjJ>,/., vol. xvi., 

 1900. 



