CONTENTS 



PART I. GENERAL. 



PAGE 



Historical and Introductory ... ... ... ... ... ... ... i 



Definition and Limitation of the term li Internal Secretion "... ... 5 



Classification ... ... ... ... ... ... ... ... ... 8 



The Activity of the Hormones ... ... 12 



The Origin of the Hormones ... ... 15 



Sources of Information and Methods of Investigation 16 



PART II. SPECIAL. 



THE THYROID APPARATUS 26 



Anatomy ... ... ... ... ... ... ... ... 26 



Histology ... ... ... ... ... ... ... ... 26 



Chemistry ... ... ... ... ... ... ... ... 29 



Anatomy of the Parathyroid Glands ... 31 



Histology of the Parathyroid Glands ... ... ... 32 



History of the Development of the Organs of the Neck ... 33 



Comparative Anatomy of the Parathyroid Glands ... 34 



Physiology of the Thyroid Apparatus ... ... 36 



Historical 36 



Tetania Parathyropriva ... 39 



Tetany in Man 44 



Other Pathological Conditions in Man arising from 

 Derangement of the Function of the Parathyroid 



Glands ... ... ... ... ... ... ... 46 



The Therapeutics of Tetania Parathyropriva ... ... ... 47 



The Relationship between the Thyroid and Parathyroid Glands 51 



The Function of the Parathyroid Glands ... ... ... ... 55 



The Tetany Toxin ... ... ... ... ... ... 55 



The Parathyroid Glands and the Metabolism of Calcium 57 



The Point of Attack of the Hypothetical Tetany Toxin ... 59 



Physiology of the Thyroid Gland ... 62 



Experimental Extirpation ... ... ... ... ... 62 



Athyrosis and Hyperthyrosis in Man 71 



Operative Athyrosis ... ... ... ... ... ... 71 



True Athyrosis and Hyperthyrosis ... 73 



Substitution Therapy 83 



The Metabolic Changes in Hypothyrosis and the manner 

 in which they are influenced by the Exhibition of 



Thyroid Extract 88 



The Physiological Effects of Thyroid Substances 89 



Experimental Hyperthyroidism ... ... ... ... 92 



Hyperthyroidism in Man ... ... ... ... ... ... 92 



As Produced by the Exhibition of Thyroid Gland ... 92 

 Conditions which may be classed as those of true Hyper- 

 thyroidism ... ... ... ... ... ... ... 93 



Theory of the Thyroid Function 104 



THE THYMUS GLAND no 



Involution of the Thymus ... 112 



Physiology of the Thymus ... 113 



Effects of Thymus Extract ... 121 



Mors Thymica and the Status Thymicolymphaticus 122 



