THE SUPRARENAL SYSTEM 167 



animals from that of the control animals. Also, the average length 

 of life of the animals under treatment was very little longer than 

 that of the control animals. From the results which I obtained I 

 was led to conclude that suprarenal substitution is not practicable 

 by these methods. 



Seeing that the exhibition of suprarenal extract is attended 

 by doubtful results in experimental suprarenal suppression, it is 

 not surprising that in Addison's disease the method has not 

 accomplished all that was at first expected of it. Charrin and 

 Langlois were probably the first to attempt the treatment of this 

 condition by means of subcutaneous injections of the glycerine 

 extract of suprarenal, obtained from dogs and horses. Since then 

 the effects of organo-therapy in Addison's disease have been tried 

 by many. 



According to Gilbert and Carnot, the clinical material may 

 be classified, according to the results obtained, in four groups. 



(1) Those cases in which organo-therapy was attended by 

 harmful results, the general condition becoming aggravated and 

 the fatal termination hastened (Rendu, Foa and Pellacani, Zucco, 

 Pitres, Posselt). Boinet, more particularly, has drawn attention 

 to the symptoms of intolerance which follow treatment with 

 organic extract in Addison's disease. He found that prolonged 

 treatment produced nervous symptoms, the most frequent being 

 a tremor similar to that of Graves's disease. 



(2) The large group of cases in which the results of treat- 

 ment were negative (Langlois, Chauffard, Grainger-Stewart, 

 Murrel, Darier, P. Marie, Galliard, Allaria and Varanini, Bendix, 

 Turner, Trevithick, Box, Huismans, Christomanos, Lange, 

 Bockhaus, Osier, Ringer and Phear, Sibley, Bittorf). 



(3) Those cases in which an improvement in certain sym- 

 ptoms was observed. The most frequent signs were a diminution 

 of the muscular asthenia, improvement of the digestive derange- 

 ments, and an increase in weight (Langlois, Mahe, Maragliano, 

 Dieulafoy, Marie, Schafer, Rolleston, Osier, Vidal, Hayem, 

 Yollbracht, Dupaigne, Spillmann, Edel, Faisans, Anderodias, 

 Althaus, Byrom-Bramwell, Gullau, Vernescu, Foster, Raven, 

 Decks, Engelhardt, Ebstein, Sellier and Verger, Posselt). 



(4) Those rare cases in which complete recovery is reported. 

 Schilling found that, in the case of a patient 16 years old, a three- 

 months' treatment with suprarenal (^ to i suprarenal capsule per 

 day) was followed by the disappearance of all previous Addisonian 

 symptoms, namely, the asthenia, anorexia, diarrhoea, and even 

 the pigmentation of the skin and mucous membranes. The 

 weight rose from 69 to 99 Ibs. Some time after recovery the 

 patient died suddenly from pneumonia, and the post-mortem 

 examination showed that there was sclerosis and softening of both 

 suprarenals. 



Beclere, Hirtz, Lambotte, and Androdias also describe cases 



