THE SUPRARENAL SYSTEM 169 



the lymph-sac of frogs, but in all his cases the implanted organ 

 perished. Boinet implanted suprarenals intraperitoneally in 

 rats and found that the implanted organ became atrophied and, in 

 some instances, resorbed. De Dominicis removed the left supra- 

 renal of dogs, leaving the vascular stem intact, and implanted the 

 organ below the kidney ; he found that, at the end of nine to 

 ten days, there was no change. Jabulay implanted fresh 

 suprarenals from dogs in two patients suffering from Addison's 

 disease, and in each instance death followed after twenty-four 

 hours. Hultgren and Andersson implanted suprarenals in three 

 cats, in each case without result. 



There is a special interest attaching to H. Poll's transplanta- 

 tion experiments. He removed the left suprarenal of rats and 

 implanted it under the skin, or in the muscles of the back, of the 

 same animal or another of the same species. By this means he 

 was enabled minutely to follow the histological changes in the 

 transplanted organ. 



Poll found that, during about the first week, regressive 

 changes preponderated. A largish necrosed focus appeared in the 

 centre of the implanted suprarenal. In addition to the central 

 medullary tissue, the zona reticularis of the cortex and the inner 

 portions of the zona fasciculata underwent degenerative changes, 

 and were destroyed. 



During the second week, a large part of the necrosed tissue 

 became gradually resorbed, giant cells being formed in the 

 process. At the same time the cells of the zona glomerulosa and 

 the external portion of the zona fasciculata became destroyed, 

 while peculiar, light, transparent cells, filled with vacuoles, were 

 formed in the cortical tissue, which afterwards disappeared, leav- 

 ing a pigmented scar. 



From the third week onwards, signs of progressive new 

 formation appeared. Minute regenerative foci were formed which 

 lay, partly internally and partly externally of the thickened con- 

 nective-tissue capsule. They developed into largish bodies, 

 shaped like the segment of a sphere, with cord-like arrangement 

 of cells. Later on, these cell agglomerations assumed the exact 

 appearance of cortical substance. 



The regeneration of the cortical tissue and the degeneration 

 of the medullary tissue were observed by Christiani in experi- 

 mental transplantation performed on rats. And Stilling found 

 that, when the suprarenals of rabbits were transplanted in their 

 testicles, they showed typical cortical tissue for as long as one 

 and a half to three years. 



Further information concerning the results of transplantation 

 is given by Imbert. He implanted the suprarenals of dogs in their 

 kidneys and found, in one instance, a pseudolipoma, in another, a 

 cyst, at the site of implantation. Strehl and Weiss sewed the 

 suprarenals into pockets between the muscular structure and the 



