3 1 6 LEO LOEB. 



(rt) Agglutination of blood cells. 



(/>) The formation of a gelatinous mass, and secondarily the 

 formation of fibrils from protoplasm exuded from cells and from 

 protoplasm of cells entirely dissolved. 



(f) The spreading out of the blood cells during the next few 

 hours after shedding of the blood. 



((/} The coagulation of a fibrinogenous substance. 



2. The agglomeration of the blood cells leads to the forma- 

 tion of tissue-like structures. The formation of the fibrillar in- 

 tercellular substance corresponds to the formation of fibrillar con- 

 nective tissue. By changing the cytolytic medium in which the 

 cells are suspended, the formation of an intercellular fibrillar sub- 

 stance can be prevented. By agglutination of cells which remain 

 well preserved, an epithelial arrangement of the blood cells can 

 be brought about. 



3. Inside of the normal body the blood cells do not change 

 their form ; this however takes place outside of the body, without 

 the presence of certain specifically directing chemotropic stimuli. 

 The cell protoplasm moves in contact with the solid surface to 

 which it sticks. In a similar way the leucocytes react during an 

 inflammatory process and a certain analog)' also exists between 

 this process and the movement of the epithelium during re- 

 generation. 



4. Coagulation of the blood can be prevented or inhibited by 

 receiving it in different solutions, such solutions usually having 

 also a preservative influence upon the cells. Oxalates act in a 

 similar way to other salt solutions, that is if they are very con- 

 centrated. This points to the fact that in all probability the pre- 

 cipitation of calcium is, under these conditions, not the essential 

 factor. Sodium and potassium sulphate have, in a similar way 

 as sodium nitrate and sodium and potassium chloride, an inhibit- 

 ing influence upon coagulation. The blood cells themselves, 

 however, are influenced in a different way by the two sulphates 

 and the other salts. 



5. The coagulation of the blood is inhibited by receiving the 

 blood in gelatine solutions ; collecting it in oil is without influence. 



6. The second coagulation of the lobster blood is inhibited by 

 means different from those acting on the first coagulation. The 



