3l8 LEO LOEB. 



direction in which the mechanical forces act ; mechanical factors 

 may also determine the direction of the fibrils in connective 

 tissue and bone. 



1 1 . The significance of the blood corpuscles for the coagula- 

 tion of the blood consists therefore in the following : (/) The 

 cells themselves are transformed into substances similar to fibrin, 

 (//) They accelerate a coagulation taking place in the surround- 

 ing fluid ; some facts point to the possibility that the coagulating 

 substance contained in the serum has its origin in the blood cells. 



12. Towards foreign substances introduced into the body of 

 the animal, the blood corpuscles of Limuhis do not behave as 

 actively as the blood corpuscles of mammals. An active pene- 

 tration into these foreign substances cannot be observed in 

 Limnlns, the cells only take part in the formation of the coagu- 

 lum around the foreign substance. 



