130 WALTER LAWRENCE. 



between morphology and motility of spermatozoa? These and 

 other questions are discussed in the following pages of this paper. 

 It was at the suggestion of Professor Carl R. Moore that I 

 attempted this phase of the sex problem, and I wish here to 

 express my appreciation for this and for his kindly direction 

 during the progress of the work. 



OBSERVATIONS. 



For the purpose of studying the progressive changes in the 

 degenerating testis thirty-three guinea pigs have been used in 

 which by operation one or both testes have been confined in the 

 abdomen for relatively closely graded periods of from six to one 

 hundred and thirteen days. The operation is simple and consists 

 of opening the abdomen, freeing the testis attachment to the 

 scrotum, and elevating the testis through the open inguinal 

 canal into the abdomen ; to secure permanency in this position the 

 inguinal canals have been closed by sutures. The blood supply, 

 nerve connections and ductus deferens are thus subjected to 

 no interference. 



A. SEMINIFEROUS TUBULE DEGENERATION. 



Six-day Cryptorchid Testes. Observed at the end of six days 

 retention in the abdomen the testis of an adult breeding guinea 

 pig shows but minor macroscopic changes; the organ may 

 appear somewhat hypenemic. Microscopical changes, however, 

 are pronounced. The majority of the seminiferous tubules are 

 abnormal, although the amount of alteration is variable. The 

 diameters of the tubules are unchanged, and the intertubular 

 spaces appear normal. In most cases the contents of the tubules 

 are so shattered and disarranged as to bear little resemblance 

 to the normal condition, while in a few the zones of spermato- 

 gonia, spermatocytes, spermatids and spermatozoa can be made 

 out. On more careful examination individual cells within the 

 tubules are seen to be swollen and granular, and in many cases 

 more or ess completely fragmented; numerous vacuoles appear 

 among the cells constituting the germinal epithelium. From 

 this it can be readily determined that some rapidly destructive 

 process has involved all the tubules. The greater part of the 



