186 J. DUESBERG. 



globule rouge. Un examen attentif revele un rapport etroit 

 des capillaires avec les espaces intercellulaires. " 



Similar observations on other glands with internal secretion 

 have been made, notably the following: Hultgren and Andersson 

 (1899) describe the secretion products in the medullar part of 

 the suprarenal in mammals as granules which are expelled into 

 the bloodvessels (see pp. 268-269): "Dies geschieht entweder 

 durch das Wandern der kleinen Korner durch die Wandung 

 der Gefasse, wie dies besonders an den Venen beobachtet wird, 

 oder, es wird das Endothel der Capillaren an gewissen Stellen 

 zersprengt und die Zellen treten mit dem Gefasslumen in direkter 

 Verbindung." 



In this case the fate of the secretion product is very clearly 

 shown. Colson (1910) finds in the same gland intercellular 

 spaces filled with the substance secreted by the cells. Appar- 

 ently the cell-bodies are, to a certain extent, liquified, since there 

 appear to be no definite boundaries between cells and intercellular 

 spaces. These spaces are, in Colson's opinion, the same that 

 Kumita, as reported above, found in communication with the 

 lymphatic system. Van der Stricht (1912), in the corpus luteum, 

 finds also that the secretion product of the lutein cells is accumu- 

 lated in the intercellular spaces; in some cases this intercellular 

 space is an axial cavity around which the cells are oriented as in 

 an epithelium. 



Finally, there are within the interstitial cells certain very 

 peculiar constituents, which are represented in Figs. 6, 9, 10, II 

 and 13. They have the appearance of a sort of huge network. 

 In a number of cells the meshes of this network are small and the 

 trabeculse are thin, while in others the meshes are wide and the 

 trabeculse quite thick. The extremes are shown in Figs. 9 and 

 n, but all stages of transition between these two types can 

 be found; one of these is seen in Fig. 10. The resemblance 

 of this network to some apparatuses of Golgi is indeed very 

 striking, but the results obtained with the method of Ramon 

 y Cajal, which have already been described, show that the 

 apparatus of Golgi in these cells is something entirely dif- 

 ferent. There is also a certain resemblance to some of the 

 trophospongia pictured by Holmgren (1904), a point which will 



