48 PHYSIOLOGY CHAP. 



the skin. From this last very apparent symptom, he named the 

 new form of disease " bronzed skin." Addisou believed it to 

 depend on deficiency or functional insufficiency of the suprarenals, 

 of which he recognised the great physiological importance. He 

 further held that there was a relation between the absence or 

 diminished function of the suprarenals, and the amount of pig- 

 ment deposited in the skin. By diligent research into the 



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s&v v!iii ffiit^ 



'^sr^i^SS 



V- O- .',-', ,v 



li m H : 



'i^jpS r.:'^*/"'* v v' BY 

 NV^ v .. S^fyJ i L \ 



l-'n.. lo. Transverse section of abdominal aortic paraganglion of adult cat. (Vassale.) , sym- 

 pathetic ganglion ; b, b, b, nerves ; c, paragangliar or chroinattine tissue. 



pathological anatomy of almost every one who had died of 

 " bronzed skin," he discovered profound alterations in the capsules 

 of various kinds, more particularly of a tuberculous nature. 



Starting from Addison's researches, Brown-Sequard (1856) 

 performed a series of experiments on animals, and came to the 

 same conclusion as the English pathologist, viz. : that the supra- 

 renal capsules were organs indispensable to life. 



On destroying the capsules, Brown-Sequard found that they 



