CONTENTS. xvii 



PAGE 



458. The corresponding changes in the mammal 720 



459. The nature and meaning of these changes ..... 721 

 460. Views as to the manner in which glycogen is stored in the hepatic 



cells. By simple dehydration of sugar ..... 722 

 461. The glycogen formed by a product of the metabolism of the hepatic 



cells. Comparison of the two views ...... 723 



462. The uses of glycogen. The formation of fat as a store of carbon - 



holding material 725 



463. Glycogen in muscle 728 



464. Glycogen in the placenta and in various tissues .... 729 



Diabetes. 



465. Artificial diabetes 730 



466. The nerves of the liver 731 



467. The nervous mechanism of the diabetic puncture .... 731 

 468. Temporary diabetes from the use of drugs. Natural diabetes. The 



diminution of hepatic glycogen by arsenic and other agents . 732 



SECTION III. 



THE SPLEEN. 



469. The general structure of the spleen 735 



470. The reticulum of the spleen 736 



471. The blood vessels of the spleen and their relation to the reticulum . 737 



472. The lymphatics of the spleen. The Malpighian corpuscles . . 738 



473. The nerves of the spleen 739 



474. The spleen pulp ; the white and red corpuscles. Changes undergone 



by the latter 739 



475. The movements of the spleen. The spleen curve .... 740 



476. The chemical constituents of the spleen 742 



SECTION IV. 



THE FORMATION OP THE CONSTITUENTS OF BILE. 



477. The formation of bilirubiu from haemoglobin ..... 744 



478. The nature of and preparations towards this formation . . . 746 



479. The formation of bile acids 747 



480. The relations of the secretion of bilirubin to the secretion of bile 



acids 748 



481. The relation of the secretion of bile to the formation of glycogen . 749 



SECTION V. 

 ON UREA AND ON NITROGENOUS METABOLISM IN GENERAL. 



482. Urea the end-product of the metabolism of proteid matter . . 750 



483. Urea probably the result of a series of changes .... 751 



484. The kreatin of muscle in its relations to urea 751 



485. Difficulties presented by the normal presence of kreatin in urine . 752 



486. The nitrogenous metabolism of the nervous tissues . 753 



