Exercise at high altitudes 



277 



condition, the physical signs of which were increased frequency of 

 the pulse and violent panting. The effect on the dissociation curve 

 is typical. The curve was pushed to the right. Mathison's normal 

 dissociation curve as determined before going to Col d'Olen is shown 



in Fig. 135. It has the equation y = 100 n , the constants being 



1 T J\.3C 



K = '000212, n = 2'5. The curve obtained at Col d'Olen immediately 

 after returning from the climb is also shown, together with the 

 points upon it which were actually determined. It has the following 

 constants: w=2'5, ^='000140. 



FIG. 135. Changes in Mathison's dissociation curve caused by climbing 1000 feet 

 in 19 minutes, and their disappearance. 5 ruins. x 20 mins. o 2 hours 

 after exercise. 



In twenty minutes Mathison's alveolar carbonic acid pressure had 

 dropped from 37 mm. to 27 mm., and a couple of determinations of 

 his dissociation curve under the new conditions indicated that it was 

 mesectic within the limits of error of the determinations, and by 

 8 p.m., two hours and a quarter after the experiments, he had settled 

 down to his permanent condition. There was an acidosis equivalent 

 to '018 / f lactic acid, but from this he scarcely, as far as is known, 

 receded while he was at Col d'Olen. 



