Effect of acid on dissociation curve 



57 



The simplest meaning which would attach to the words "increased 

 hydrogen ion concentration reduces the effective concentration of 

 oxygen " would be as follows : In order to obtain a given percentage 

 saturation of the blood with oxygen in the presence of the various 

 concentrations of acid, the pressure of oxygen with which the blood 

 would be in equilibrium would require to be higher in proportion to 

 the increase in the H-ion concentration : this proportion also should 

 be the same all along the curve. 



O05 -010 -015 -O20 -025 -030 -035 -040 -O45 



PRESSURE OF CO IN PERCENTAGE OF ONE ATMOSPHERE. 



FIG. 29. Dissociation curves of CO-haemoglobin in absence of oxygen, at 38 C. and 

 with various pressures of C0. 2 . 



o Blood of Douglas. Blood of Haldane. 



For instance, my blood is 45 D / saturated at 10 mm. oxygen 

 pressure in the absence of C0 2 , in the presence of 40 mm. CO 2 it is 

 45 % saturated at 24 mm. 2 : now if the relation which we have 



