The call for oxygen by the tissues 101 



of the sympathetic as well, at least on the accepted theory that 

 adrenalin action is sympathetic secretion. 



Fig. 58 shows the oxygen consumption which results from injection 

 of 1 c.c. of Yotroo' adrenalin into the jugular vein of a cat in three 

 experiments. These ran an almost even course, so that it seemed 

 allowable to average out the results. Their mean is given at the 

 bottom of the figure. From it we can not only see that the oxygen 

 use outlasts the secretion of saliva by some considerable time, but we 

 can also calculate with a fair degree of accuracy the quantity of 

 oxygen which is used as the result of a certain quantity of salivary 

 secretion. 



The Pancreas. Sufficient has probably been said about the sub- 

 maxillary to show that a great deal of knowledge has been gained 

 about it within the last ten years ; nevertheless this has only sufficed 

 really to open the door for a more exact investigation of the whole 

 problem. We have done enough to convince our readers that the 

 call for oxygen follows the functional activity of the gland, but we 

 want a much more rigid definition of the latter. Of the other organs 

 which have formed the subject of research, the pancreas' 15 ', the liver' 16 ' 

 and the suprarenal (17) glands, there is little which need be said; in the 

 case of the two former, experiments have been performed which clearly 

 increase the activity of the glands, but we have no measurements in 

 units of the increase. 



The chief interest of these experiments perhaps lies in the very 

 diverse stimuli which are used for the purpose of bringing about the 

 increase. This is an important matter, because it is clear that if 

 functional activity, when produced by stimuli of the most diverse 

 kinds, evokes a call for oxygen, we are on a much safer footing in 

 supposing that the oxygen want is the direct result of the functional 

 activity. 



So far as the pancreas was concerned the stimulus used was of 

 course secretin. The experiments were performed in collaboration 

 with Prof. Starling shortly after he and Prof. Bayliss discovered 

 the mechanism of pancreatic secretion. The experiments consisted 

 in isolating the tail of the pancreas in the dog from the rest of the 

 organ ; this may be done without upsetting the circulation. A cannula 

 is so placed that the blood from this portion may be collected with 

 ease, its rate of flow being measured at the same time and its gases 

 analysed. The experiments were done in the early days, before the 

 introduction of the differential method of blood-gas analysis, and 



