EFFECT OF FAT ON PANCKEATIC SECRETION. 121 



of gastric juice, and consequently we could not fancy that, under 

 ordinary conditions, a pancreatic secretion after fat is indirectly caused 

 by the acid of the gastric juice. Dr. Dolinsky poured fluid oil info the 

 stomach of dogs, and constantly observed a more or less considerable 

 flow of pancreatic juice. Bearing in mind the strongly inhibitory 

 effects of fat on gastric secretion, the constancy of this result afforded 

 good assurance that we had here to deal with a direct influence of fat 

 upon the pancreas. A confirmed sceptic might, however, reply that 

 possibly an acid fluid had accumulated in the stomach before our experi- 

 ment, or, as we previously indicated ourselves, that a strong psychic 

 effect might have overcome the inhibitory influence of the fat. But 

 here is an experiment instituted by Dr. Damaskin which complies with 

 the strictest requirements. A perfectly healthy dog, having two fistula? 

 one a gastric, the other a pancreatic fistula was last fed twenty 

 hours before the experiment. Beneath the orifice of the pancreatic duct 

 a metallic funnel and graduated cylinder were fastened. The gastric 

 fistula was closed by a cork through which a glass tube was led, and 

 which in turn was connected with an india-rubber tube and funnel. The 

 funnel was hung up at a suitable height, and contained 110 c.c. to 

 115 c.c. of oil. The india-rubber tube was also provided with a T-piece, 

 the transverse arm of which was connected with a second india-rubber 

 tube. At the beginning of the experiment the connecting tube was 

 clamped between the funnel and the T-piece with a Mohr's clamp, so 

 that the oil could not leave the funnel. The tube at the end of the 

 transverse arm of the T-piece remained open to allow the gastric contents 

 to escape freely. Often at the beginning of the experiment the stomach 

 secreted a clear acid fluid the psychic gastric juice. More rarely it 

 contained only a little alkaline mucus. The experimenter secluded him- 

 self in a separate room with the dog and quietly waited. The animal 

 gave up the hope of receiving anything to eat, and finally slept. 

 When the acid secretion from the stomach ceased, the experimenter 

 then cautiously closed the outflow tube and opened the clamp on the 

 oil funnel. So long as the stomach cavity remained unclosed, either no 

 pancreatic juice, or at most O5 c.c. to I'O c.c. in fifteen minutes, was 

 secreted, but three to five minutes after the pouring in of the oil the 

 flow was quite distinctly increased, and after fifteen to thirty minutes 

 attained a rate of 7 c.c. to 10 c.c. in fifteen minutes. At the same time 

 only a very small quantity of alkaline mucus collected from the stomach 

 in the lower division of the india-rubber tube ; consequently, the secre- 

 tion of pancreatic juice after the administration of fat takes place even 

 when every trace of acid contents is absent from the stomach. Some- 

 times the experiment was varied in the following way. Fifteen to 

 thirty minutes after the introduction of the oil, the clamp on the lower 



