190 EXPERIMENTAL PHARMACOLOGY 



cubic centimeters and record the results. Do you get what 

 you expected? Does the anesthesia remain regular? How 

 are the respiratory movements affected? Does the rate 

 of oxygen consumption correspond with the rapidity or 

 slowness of the respiratory movements or with the height 

 of the blood-pressure? Would you have expected these re- 

 sults? Now take one or two normal oxygen records and 

 then when the oxygen lever is getting pretty well up to 

 the top of its course inject one-half cubic centimeter of ad- 

 renaline. Watch carefully to reset your oxygen record at 

 the exact moment. Be sure before the adrenaline is in- 

 jected that the rise in the manometer writing point will 

 not interfere (catch] ivith your oxygen lever. Watch your 

 oxygen record closely and make the changes promptly. 

 Take at least two or three minutes to record this after the 

 adrenaline is injected. Do you observe any peculiar 

 changes in your records? If not, wait a Avhile and repeat 

 the adrenaline injection. 



How does morphine affect the heart? Can you detect 

 any change in the rate? Give more morphine from time 

 to time (two cubic centimeters per dose), and see if you 

 can bring on a Cheyne-Stokes form of respiration. Does 

 the anesthesia become any deeper? Examine the pupils 

 carefully. Are they in the same condition as were those 

 of the dog in Experiment XXV? Does this agree with the 

 text-book descriptions? 



Inject as much morphine as you think (from the ap- 

 pearance of the respiration, blood-pressure, etc.) the ani- 

 mal can safely stand. You may not get a Cheyne-Stokes 

 form of respiration, but many small repeated doses are 

 very liable to bring it on. Variable but constantly repeated 

 irregularities of the respiration often appear. 



Allow the animal to recover a little if it will and then 

 inject codeine (two cubic centimeters 1 c.c. = = 5 nig.). Get 

 a record of this and then increase the dose given. After 

 a few injections (and within half an hour), marked symp- 



