ACTIOX OF STRYCHNINE 21 < 



The animal will probably be very low by this time. If 

 it is still alive and the pressure is high enough inject some 

 other of the opium alkaloids, such as dionine, thebaine or 

 peronine, and try to counteract this effect by injecting 

 "epinine' : (1:1000 Burroughs, Wellcome and Company, 

 New York). ' ' Epinine ' ;t is nearly related chemically and 

 pharmacologically to adrenaline. 



2. After the animal dies, if it is a female, try to pass a 

 catheter (Fig. 206) through the urethra into the bladder. 

 Consult Fig. 207 to do this. A catheter made of a very 

 small glass tube slightly curved at the end is very satis- 

 factory for this purpose. Could you thus pass a catheter 

 in a living animal? Isolate the left kidney (or the spleen) 

 and place it in an oncometer. Place a loop of intestine in 

 an oncometer (see Fig. 157). 



EXPERIMENT XXXI. 



Strychnine. (Frog: Action on the Cord.) 



1. Pith a frog and attach it to a frog board. Dissect 

 loose the right tendo Achillis and gastrocnernius muscle 

 but do not injure the tissues of the thigh. Cut the tendo 

 Achillis long and drive a carpet tack through the knee joint 

 region (avoid the artery and sciatic nerve) as shown in 

 Fig. 208. The tack gives a firm point of attachment for 

 the gastrocnemius muscle. Then place the frog board in 

 a large clamp and arrange all apparatus as shown in the 

 illustration. The drum should have a fairly rapid speed 

 and the muscle lever should write near the bottom of the 

 drum (leaving enough space below for the time record). 

 With a hypodermic needle inject into the dorsal lymph sac 

 of the frog one cubic centimeter of strychnine sulphate 

 solution (one cubic centimeter equals one-half milligram). 

 Wait about three minutes for the drug to be absorbed and 

 then start the drum. The frog will soon show a marked 



