ACTION OF STRYCHNINE 225 



cial pupillary changes ? Do you get any results resembling 

 a Cheyne-Stokes respiration? Deepen the anesthesia a 

 little and see if you can depress the action of the drug a 

 little. Try touching the animal from time to time or jar 

 the board a little and note the effect. What parts of the 

 central nervous system are mainly affected? What is the 

 difference between epileptiform, clonic and tonic convul- 

 sions? How do you explain these? How long did it take 

 for the action of the drug to come on? Do you get satis- 

 factory oncometer tracings! What mechanical factors are 

 concerned in the production of these? Your apparatus 

 should be carefully arranged so you can hold the stands, 

 etc., down firmly on the table to prevent them from being 

 shaken out of place. 



Fig. 213. Glass ureteral canmila with rubber tube connection. About one-half natural size. 



Inject some adrenaline into the vein. How does this 

 affect the animal? Secure records of as many typical 

 convulsions as you can. Many of these will probably lie 

 spoiled by movements of the apparatus. Crowd on enough 

 ether to check the convulsions, then open the bladder and 

 insert a cannula (or pass a catheter if you can) and close 

 the abdomen firmly with hemostats. Draw off some urine 

 and test it for reducing substances. What action will 

 strychnine have on the glycogen stores of the body? How 

 is this brought about? What mechanisms are concerned? 

 How is strychnine excreted? Could you get a positive test 

 for it in the urine? How long does the drug remain in 

 the body before it is excreted? What bearing does this 

 have on the treatment of strychnine poisoning? 



