226 EXPERIMENTAL PHARMACOLOGY 



Kill the animal by a large dose of the drug. AVliat is 

 the immediate cause of death! 



If time permits open the abdomen and dissect out both 

 ureters (Fig. 162) and trace their course to the bladder. 

 Could you tie a cannula (Fig. 213) in each ureter and col- 

 lect the urine from each kidney separately? What is the 

 innervation of the ureters ? 



EXPERIMENT XXXV. 



Strychnine. (Ether, Morphine, Chloral Hydrate.) (Dog: 

 Blood-pressure, Respiration, Oxygen Consumption, 



Air Embolism.) 



1. Read over carefully the section on oxygen consump- 

 tion given in Experiment XXVIII, page 177. The ap- 

 paratus there used is of a very simple form and will be 

 available in most laboratories. A better but somewhat 

 more complicated form is shown in- Fig. 172. This figure 

 shows in addition a special arrangement for measuring 

 the oxygen each time it is run in. If only enough water be 

 placed in the pressure bottle to allow 200 or 300 cubic 

 centimeters (the bottom of the bottle must first be filled up 

 to the level of the spout) to run down into the graduate* 1 

 cylinder at a time, then the measuring of this amount of 

 oxygen before it is run into the pan becomes automatic 

 and can quickly be done each time. If the oxygen tank 

 be opened a little oxygen will be forced through the 

 T-tube into the graduated cylinder. This oxygen is un- 

 der pressure and will drive the water in the cylinder up 

 into the pressure bottle. If it is especially desired for 

 greater accuracy, the bottle can then be lowered to the 

 level of the graduated cylinder to avoid compression of 

 the oxygen while its volume is being measured, but this 

 is not generally necessary, for the compression of the 

 oxygen in the graduated cylinder by the column of water 

 up to the pressure bottle will be the same each time and 



