ACTION OF CONIHSTE 267 



order from above down, oncometer, blood-pressure, respira- 

 tion, base line and time signal. Take a normal record, in- 

 cluding a vagus stimulation, and then inject one cubic centi- 

 meter of coniine solution. Watch the pupils as the drug is 

 injected. Do you obtain satisfactory results? How did the 

 heart beats appear just after the drug was injected? How 

 do you account for this? Stimulate the vagus nerve again 

 and record the result. Has any more saliva been secreted 1 

 How do you account for any changes in the oncometer trac- 

 ing. Inject a small dose of adrenaline to see if your appa- 

 ratus, etc., is working satisfactorily. 



Inject a second dose of coniine. This may be larger or 

 smaller than the first dose depending on the reactions 

 brought about by previous injections. Do you get a fall in 

 blood-pressure! If so how do you explain it? If you get a 

 rise what is the cause of this? Stimulate the vagus again 

 and explain its action on the heart. Observe the corre- 

 sponding pupil while the nerve is stimulated. Stimulate the 

 chorda and see if any change has been produced in it as 

 shown by the salivary secretion. Explain any changes ob- 

 served. From time to time give more coniine as the animal 

 will tolerate it. Be ready to apply artificial respiration if 

 necessary. At intervals stimulate the vagi and chorda and 

 if a response fails to be obtained explain its cause. Then 

 follow the course of the chorda tympani back under the jaw 

 bone as far as you can (do not injure the duct) and finally 

 push the electrodes far down into the hilus of the gland and 

 stimulate. Can you cause any visible increase in the flow of 

 saliva by this procedure ? What is the purpose of this part 

 of the experiment? Give some adrenaline and see if the 

 pupils respond normally. 



Open the abdomen, follow the right side of the stomach 

 around posteriorly and pick up the duodenum. In the 

 angle between this and the stomach ( inferiority) is located 

 the pancreas. Eefer to Figs. 244 and 245 and find the lower 

 end (tail) of the pancreas. Follow this to the place where 



