PILOCARPINE, ARECOLINE, ATROPINE 275 



From moment to moment observe the eye ground and 

 watch for any change in the rate of capillary movement. 

 If yon succeed well in getting a change, then with a fine 

 pointed hypodermic syringe inject into the pericardium 

 one-half cubic centimeter of atropine solution (one cubic 

 centimeter equals one milligram). What changes do you 

 observe in the retinal circulation! How do you explain 

 this? 



EXPERIMENT LXVII. 



Pilocarpine or Arecoline and Atropine. (Dog, Cat, Rabbit, 

 and Pigeon or Chicken: Pupil.) 



1. Into the right eye of as many of these animals as 

 may be available inject about twenty drops of pilocarpine 

 (one cubic centimeter equals five milligrams) or arecoline 

 (one cubic centimeter equals three milligrams) solution. 

 Open the lids and fill the conjunctional sac as completely 

 as possible and keep the solution in as long as you can. 

 Into the left eye of each animal drop atropine solution (one 

 cubic centimeter equals four milligrams). Leave the ani- 

 mals alone quietly and at intervals of a few minutes com- 

 pare the two eyes. Do you note any pupillary changes? 

 Explain these. 



EXPERIMENT LXVIIL 



Pilocarpine, Atropine. (Dog: Blood-pressure, Respiration, 

 Salivary and Pancreatic Secretions.) 



1. Anesthetize a ten kilo dog (ether only) and arrange 

 to record blood-pressure and respiration. Insert a cannula 

 in Wharton's duct (Figs. 237, 238, 239 and 240) and dis- 

 sect out the chorda tympani. Stimulate it and get a nor- 

 mal secretion. 



Open the abdomen and insert a cannula into the large 



