ACTION OF NICOTINE 



305 



Take a normal tracing (stimulate the vagi and get the 

 cardiac effect) and then inject one cubic centimeter (less 

 if the animal is small) of nicotine solution. Watch the pu- 

 pil as the drug is injected. What do you observe? Wait 



Fig. 270. Tracing showing the action of a fatal dose of nicotine on the blood- 

 pressure and respiration of a dog anesthetized with nitrous oxide. Can you see the 

 evidence of a preliminary stimulation (followed by paralysis) of the cardie-inhibitory 

 ganglia? 



for the effects to pass off. What do your records show 

 for the intestine and leg? How can you explain these? 

 Inject one-half cubic centimeter of adrenaline. How does 

 this drug compare with nicotine in action? On what struc- 



