PHYSOST1GMINE, HYOSCINE, ADRENALIN K 339 



What conclusions can you draw? Do atropine and adren- 

 aline act on the lungs of the turtle in the same way that 

 they do on the dog's lungs? Could you prove your conclu- 

 sions? 



EXPERIMENT LXXXIX. 



Physostigmine, Hyoscine, Adrenaline, (Trimethylamine). 



(Dog: Respiration, Blood-pressure, Intestinal 



Contractions.) 



(See following experiment.) 



1. Arrange a dog (a cat or rabbit may be used) for 

 recording blood-pressure, respiration, and intestinal con- 

 tractions. (For the latter purpose use the ringer cot, cathe- 

 ter, burette, and tambour method.) The three injecting 

 burettes contain physostigmine (one cubic centimeter 

 equals one-half milligram), hyoscine (one cubic centimeter 

 equals one milligram atropine or hyoscyamine may be 

 substituted could you use homatropine?) and adrenaline 

 (or trimethylamine hydrochloride one cubic centimeter 

 equals one milligram). 



Take a normal record and then inject two cubic centi- 

 meters (for a cat or rabbit one-half cubic centimeter) of 

 physostigmine. How is the respiratory tracing affected ! 

 Do you get normal results from the heart and intestine I 

 Was the dose too large or too small? The instructor may 

 be able to advise you on this point, because he can observe 

 the action of the same drug solution you are using in the 

 experiments performed by other members of the class. As 

 soon as the action of the eserine becomes well marked in- 

 ject a dose (one-half cubic centimeter for a dog) of 

 adrenaline (or trimethylamine, one cubic centimeter). 

 What action has this on the respiration? Does it counter- 

 act the eserine? Explain the relations of these two drugs 

 to the respiration both centrally and peripherally. How is 



